Unrepaired single-stranded dna breaks can lead to double-stranded dna breaks during the next round of replication. Which repair pathway would be most appropriate for repairing double-stranded dna breaks?.
Nonhomologous end joining would be most appropriate for repairing double-stranded DNA breaks.
How are double stranded breaks in DNA repair?
Homologous recombination and nonhomologous DNA end joining are the two main mechanisms for mending double-strand DNA breaks, which often occur in eukaryotic cells.
DNA ends that need to be repaired have a different chemistry as a result of the many causes of DSBs.
The enzymes of the NHEJ pathway display a remarkable level of structural tolerance in the variety of DNA end substrate configurations upon which they may function over the course of NHEJ development.
The nuclease, polymerases, and ligases of NHEJ are the most versatile and mechanistically adaptable enzymes in each of their classes in vertebrate cells.
To learn more about double-stranded DNA breaks from the given link
